A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer.
- Author:
Jung Hwan LEE
1
;
Ha Young SHIN
;
Seung Min KIM
;
Il Nam SUNWOO
Author Information
- Publication Type:Case Report
- Keywords: Lambert-Eaton myasthenic syndrome; small-cell lung carcinoma; myasthenia gravis
- MeSH: Antibodies; Calcium Channels; Extremities; Eye; Follow-Up Studies; Humans; Lambert-Eaton Myasthenic Syndrome; Lung; Lung Neoplasms; Male; Mouth; Myasthenia Gravis; Neuromuscular Junction Diseases
- From:Journal of Clinical Neurology 2012;8(4):305-307
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. CASE REPORT: A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L. CONCLUSIONS: We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
