Primary Histiocytic Sarcoma of the Central Nervous System.
- Author:
Hoonsub SO
1
;
Sun A KIM
;
Dok Hyun YOON
;
Shin Kwang KHANG
;
Jihye HWANG
;
Chong Hyun SUH
;
Cheolwon SUH
Author Information
- Publication Type:Case Report
- Keywords: Histiocytic sarcoma; Central nervous system; Methotrexate; Cytarabine
- MeSH: Biopsy; Central Nervous System*; Cerebrum; Cytarabine; Demyelinating Diseases; Diagnosis; Diagnostic Errors; Drug Therapy; Histiocytes; Histiocytic Sarcoma*; Humans; Lymphoma; Methotrexate; S100 Proteins; Sarcoma; Spinal Cord
- From:Cancer Research and Treatment 2015;47(2):322-328
- CountryRepublic of Korea
- Language:English
- Abstract: Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS histocytic sarcoma involving the cerebral hemisphere and spinal cord, who had been initially misdiagnosed as demyelinating disease. Two biopsies were necessary before a correct diagnosis was made. A histologic examination showed bizarre shaped histiocytes with larger nuclei and nuclear atypia. The cells were positive for CD68, CD163, and S-100 protein. As a resection was not feasible due to multifocality, he was treated with highdose methotrexate, but showed no response. As a result, he was switched to high dose cytarabine; but again, showed no response. The patient died 2 months from the start of chemotherapy and 8 months from the onset of symptoms. Since few patients with this condition have been described and histopathology is difficult to diagnose, suspicion of the disease is essential.
