Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma.

Author: Jae Heun CHUNG ¹ ; Seung Kug BAIK ; Su Hee CHO ; Seong Geun KIM
Author Information

1. Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. sgkimpatheny@gmail.com
Publication Type:Case Report
Keywords: Cisplatin; Myelinolysis; Central pontine; Hyponatremia; Cerebellar ataxia
MeSH: Anemia; Ataxia; Brain; Cerebellar Ataxia*; Cholangiocarcinoma*; Cisplatin; Drug Therapy*; Dysarthria; Female; Hematologic Tests; Humans; Hyponatremia*; Infusions, Intravenous; Magnetic Resonance Imaging; Middle Aged; Myelinolysis, Central Pontine*; Neutropenia
From:Cancer Research and Treatment 2015;47(2):329-333
CountryRepublic of Korea
Language:English
Abstract: A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine region, sparing the basis pontis. Here, we report on the case of a patient with reversible cerebellar ataxia related to extrapontine myelinolysis without hyponatremia after treatment with cisplatin-based chemotherapy for cholangiocarcinoma and discuss the literature on cerebellar ataxia in patients who underwent recent chemotherapy for malignancy.