The effect of iodine solution for reducing mucosal secretion in augmentation ileocystoplasty in rats.
- Author:
Jaei Young YOON
1
;
Tae Kon HWANG
;
Yong Hyun PARK
Author Information
1. Department of Urology, Catholic University, Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ileocystoplasty;
Iodine solution;
Reducing mucosal secretion
- MeSH:
Animals;
Cystectomy;
Fibrosis;
Goblet Cells;
Humans;
Intestinal Mucosa;
Iodine*;
Mucous Membrane;
Mucus;
Rats*;
Urinary Bladder
- From:Korean Journal of Urology
1993;34(1):51-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
With the increasing use of intestinal segment for bladder substitutes or augmentation, excessive mucus secretions secreted by goblet cells in the transplanted intestinal mucosa elicits various problems in patients. During ileocystoplasty, three kinds of concentration of iodine solution (0.5 %, 0.25 %. 0.125 %) were applied on the mucosa of ileal segment for reducing mucosal secretion. 24-hour urine was collected for each rat weekly and then cystectomy was performed at 4 weeks after ileocystoplasry. The amount of lyophilizod dry mucus was increased in 2-3 weeks and decreased thereafter, and it was significantly lower in the group using 0.25 % iodine solution than in other groups. Fibrosis was not significant in all experimental rats compare to control group by Masson-trichromr staining. With this method further investigation will be needed for reducing the mucus secretion.
