Life-Threatening Anaphylactoid Reaction in an Acute Ischemic Stroke Patient With Intravenous rt-PA Thrombolysis, Followed by Successful Intra-Arterial Thrombolysis.
- Author:
In Serk PARK
1
;
A Hyun CHO
;
Seung Jae LEE
;
Joong Seok KIM
;
Kwang Soo LEE
;
Yeong In KIM
Author Information
- Publication Type:Case Report
- Keywords: Recombinant tissue plasminogen activator; Acute ischemic stroke; Anaphylactoid reaction
- MeSH: Adult; Humans; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator
- From:Journal of Clinical Neurology 2008;4(1):29-32
- CountryRepublic of Korea
- Language:English
- Abstract: An anaphylactoid reaction to recombinant tissue plasminogen activator (rt-PA) is an uncommon but fatal complication. A 39-year-old man was admitted within 1 hour of the onset of a right hemispheric stroke. He was not taking any specific medication, including angiotensin-converting enzyme (ACE) inhibitors. A systemic anaphylactoid reaction developed immediately after rt-PA infusion. However, the symptoms were improved after treatment with a steroid and antihistamine. Subsequent intra-arterial thrombolytic therapy resulted in complete recanalization and clinical improvement. To our knowledge, this is the first report of a life-threatening anaphylactoid reaction after rt-PA treatment followed by successful intra-arterial thrombolytic therapy in a patient who had not taken an ACE inhibitor.
