Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation.
- Author:
Ja Young JANG
1
;
Tae Su KIM
;
Jingmei CAI
;
Jihyun KIM
;
Youngeun KIM
;
Kyungha SHIN
;
Kwang Sei KIM
;
Sung Pyo LEE
;
Myung Hwa KANG
;
Ehn Kyoung CHOI
;
Man Hee RHEE
;
Yun Bae KIM
Author Information
- Publication Type:In Vitro ; Original Article
- Keywords: Platelet aggregation; thromboxane B2; thrombosis; perilla oil
- MeSH: Animals; Aspirin; Blood Platelets*; Collagen; Perilla*; Platelet Aggregation*; Platelet-Rich Plasma; Rats; Thrombin; Thrombosis*; Thromboxane B2
- From:Laboratory Animal Research 2014;30(1):21-27
- CountryRepublic of Korea
- Language:English
- Abstract: The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B2 formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.
