Allogeneic Blood Transfusion Given Before Radiotherapy Is Associated with the Poor Clinical Outcome in Patients with Cervical Cancer.
10.3349/ymj.2008.49.6.993
- Author:
Myong Cheol LIM
1
;
Joo Young KIM
;
Tae Hyun KIM
;
Sohee PARK
;
Sun Young KONG
;
Jung Hyun YOON
;
Sokbom KANG
;
Sang Soo SEO
;
Sang Yoon PARK
Author Information
1. Research Institute and Hospital, National Cancer Center, Gyeonggi, Korea. jooyoungcasa@ncc.re.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Anemia;
blood transfusion;
cervical cancer;
metastasis;
radiotherapy
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Anemia/etiology/therapy;
Blood Transfusion/*adverse effects;
Carcinoma, Squamous Cell/complications/radiotherapy/secondary/therapy;
Female;
Humans;
Middle Aged;
Prognosis;
Treatment Outcome;
Uterine Cervical Neoplasms/complications/*radiotherapy/*therapy;
Young Adult
- From:Yonsei Medical Journal
2008;49(6):993-1003
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To analyze the effect of allogeneic blood transfusion on clinical outcome in 119 patients with stage IIB cervical cancer who were treated with radiotherapy +/- chemotherapy. PATIENTS AND METHODS: Medical records were examined for hemoglobin levels before and during radiotherapy, history of allogeneic blood transfusions and the time point when transfusions were given. These factors were retrospectively analyzed along with other clinical risk factors for influences on the patients' clinical outcomes. RESULTS: Thirty-two patients (26.9%) received packed red blood cell transfusion (mean, 3.4 units; range, 1-12 units) before or during radiotherapy. Median follow-up period was 39.3 months (range, 7.6-58.4 months). Patients with history of transfusion showed poorer metastasis-free survival and a trend toward poorer overall survival than non-transfused patients. When patients who received transfusions were sub-divided by the time of transfusion, those who received transfusions before radiotherapy had significantly poorer clinical outcome than those who received transfusions during radiotherapy. In a multivariable analysis, patients with pretreatment transfusion showed a higher risk of distant metastasis (HR = 3.75, 95% CI: 1.28-12.15, p = 0.017) and decreased overall survival rates (HR = 4.62, 95% CI: 1.15-18.54, p = 0.031) compared with those of other patients. CONCLUSION: Our results suggest that allogeneic blood transfusions given before radiotherapy may be associated with higher incidence of distant metastases and decreased survival in patients with stage IIB cervical cancer.
