A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors.
10.3349/ymj.2008.49.6.1055
- Author:
Joo Hee CHANG
1
;
Young Se KWON
;
Bok Ki KIM
;
Byong Kwan SON
;
Jee Eun LEE
;
Dae Hyun LIM
;
Soon Ki KIM
;
Joon Mi KIM
;
Sung Kil KANG
Author Information
1. Department of Pediatrics, Inha University College of Medicine, Incheon, Korea. hee715@freechal.com
- Publication Type:Case Report
- Keywords:
Hepatitis;
Mycoplasma pneumoniae;
depression;
coagulation factors
- MeSH:
Acute Disease;
Blood Coagulation Factors/metabolism;
Child, Preschool;
Hepatitis A/blood/diagnosis/*etiology;
Humans;
Male;
Mycoplasma pneumoniae/pathogenicity;
Partial Thromboplastin Time;
Pneumonia, Mycoplasma/blood/*complications
- From:Yonsei Medical Journal
2008;49(6):1055-1059
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection.
