A Case of Primary Gastric ALK-Positive Anaplastic Large-Cell Lymphoma.
- Author:
Woo Sung CHANG
1
;
Woo Jin JEONG
;
Kyung Hoon KANG
;
Jang Hoon KWON
;
Jong Sam HONG
;
Dae Woon EOM
;
Gab Jin CHEON
Author Information
1. Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea. jwoojini@gnah.co.kr
- Publication Type:Case Report
- Keywords:
Anaplastic lymphoma kinase;
Lymphoma;
Non-Hodgkin;
Stomach neoplasm
- MeSH:
Adult;
Brain;
Cyclophosphamide;
Doxorubicin;
Female;
Humans;
Lymphocytes;
Lymphoma;
Lymphoma, Large-Cell, Anaplastic;
Lymphoma, Non-Hodgkin;
Methotrexate;
Neoplasm Metastasis;
Phosphotransferases;
Prednisolone;
Receptor Protein-Tyrosine Kinases;
Stomach Neoplasms;
Upper Gastrointestinal Tract;
Vincristine
- From:Korean Journal of Medicine
2012;83(6):752-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anaplastic large-cell lymphoma (ALCL) is a rare subgroup of non-Hodgkin's lymphoma. Primary gastric ALCL is extremely rare. Patients with anaplastic lymphoma kinase (ALK)-positive primary systemic ALCL are known to have better overall survival than those with ALK-negative ALCL. We herein report a case of primary gastric ALK-positive anaplastic large-cell lymphoma. A 37-year-old woman presented with postprandial epigastric pain for 2 months. Endoscopic examination of the upper gastrointestinal tract showed multiple variably sized, round, elevated lesions with friable crater-erosion on the body and fundus. Pathologic examination revealed atypical large lymphoid cell infiltration in the lamina propria; the cells were positive for CD3, CD30, and ALK. We diagnosed the patient with ALCL. She underwent a cycle of chemotherapy with cyclophosphamide, adriamycin, vincristine, and prednisolone. However, she developed brain metastases. Despite two cycles of palliative chemotherapy with high-dose methotrexate for brain metastases, she died due to ALCL progression.
