A case of generalized argyria presenting with muscle weakness.
10.1186/s40557-017-0201-0
- Author:
Inha JUNG
1
;
Eun Jeong JOO
;
Byung seong SUH
;
Cheol Bae HAM
;
Ji Min HAN
;
You Gyung KIM
;
Joon Sup YEOM
;
Ju Yeon CHOI
;
Ji Hye PARK
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181 South Korea. iamjoo@hanmail.net.
- Publication Type:Case Report
- Keywords:
Generalized argyria;
Silver;
Myopathy;
Polyneuropathy
- MeSH:
Aged;
Argyria*;
Basement Membrane;
Biopsy;
Diagnosis, Differential;
Eating;
Emergency Service, Hospital;
Female;
Fever;
Forehead;
Humans;
Muscle Weakness*;
Muscles;
Muscular Diseases;
Myofibrils;
Myositis;
Neural Conduction;
Nose;
Pathology;
Pigmentation Disorders;
Polyneuropathies;
Pyelonephritis;
Rehabilitation;
Silver;
Skin;
Skin Pigmentation;
Steroids;
Sweat Glands;
Thigh
- From:Annals of Occupational and Environmental Medicine
2017;29(1):45-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy. At presentation, diffuse slate gray-bluish pigmented patches were noticed on her face and nails. Two months prior to visiting our hospital, she was diagnosed with inflammatory myopathy and given steroid therapy at another hospital. We performed a nerve conduction study that revealed polyneuropathy. In skin biopsies from pigmented areas of the forehead and nose, the histopathologic results showed brown-black granules in basement membranes of sweat gland epithelia, which are diagnostic findings of argyria. We reviewed pathology slides obtained from the left thigh muscles and found markedly degenerated myofibers with disorganization of myofibrils without inflammatory reactions, consistent with unspecified myopathy, rather than inflammatory myopathy. The patient was diagnosed with generalized argyria with polyneuropathy and myopathy and transferred to a rehabilitation institution after being tapered off of steroids. CONCLUSIONS: Clinicians should be aware of clinical manifestations of argyria and consider it in differential diagnosis when they examine patients who present with skin pigmentation and muscle weakness.
