No Association of TGF-beta Gene Polymorphism with the Progression of Autosomal Dominant Polycystic Kidney Disease(ADPKD) in Korean Patients.
- Author:
Jung Geon LEE
1
;
Cu Rie AHN
;
Hyun Seon EO
;
Jin Ju NO
;
Keun Hwa KIM
;
Eun Joo LEE
;
Yeong Hwan HWANG
;
Dae Yeon HWANG
;
Yoon Kyu OH
;
Se Han LEE
;
Joung Eun LEE
;
Yon Su KIM
;
Jin Suk HAN
;
Suhng Gwon KIM
;
Jung Sang LEE
Author Information
1. Department of Internal Medicine, Eulji Medical College, Seoul, Korea. curie@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Autosomal dominant polycystic kidney disease(ADPKD);
TGF-beta gene;
polymorphism;
Korean
- MeSH:
Alleles;
Atrophy;
Fibrosis;
Genetic Loci;
Humans;
Hypertension;
Inflammation;
Polycystic Kidney, Autosomal Dominant*;
Prognosis;
Renal Insufficiency;
Transforming Growth Factor beta*
- From:Korean Journal of Nephrology
2002;21(1):39-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Two genetic loci, PKD1 and PKD2, have been identified as being responsible for ADPKD, and PKD1 is known to be associated with poor prognosis. However, the presence of intrafamilial clinical diversity suggests the presence of disease-modifying loci. Because the mechanism of renal failure in ADPKD includes cystic growth and tubulointerstitial atrophy and fibrosis, we studied the associations between two cytokine gene polymorphisms in the TGF-beta gene, which are known to be related with chronic tubulointerstitial inflammation, and ADPKD progression in Korean patients. METHODS: 47 normal controls and 114 individuals with ADPKD were genotyped by PCR-RFLP, and the TGF-beta gene leader sequence of T869C(Leu10Pro) variant was compared with MspA1I and G915C (Arg25Pro) with BglI. Statistic significances were determined using the Chi-square test. RESULTS: The distribution of alleles for the TGF-beta Leu10Pro polymorphism in ADPKD was : T 52%, C 48%, which was similar to the Korean(56 : 44, p= 0.670) and Western controls(65 : 35), and in addition, no differences were found between the CRF and the non-CRF groups(p=0.571) or the early hypertension and the normotension groups(p=0.252). The distribution of alleles for the TGF-beta Arg25Pro polymorphism was all GG type, which was different from Western controls(90 : 10, p=0.000). CONCLUSION: Our results suggest that the polymorphism at Arg25Pro of TGF-beta in Korean population has different allele distribution from Western, and the polymorphism at Leu10Pro of TGF-beta has no association with the renal progression of Korean ADPKD patients.
