C-Peptide-Based Index Is More Related to Incident Type 2 Diabetes in Non-Diabetic Subjects than Insulin-Based Index.
10.3803/EnM.2016.31.2.320
- Author:
Jong Dai KIM
1
;
Sung Ju KANG
;
Min Kyung LEE
;
Se Eun PARK
;
Eun Jung RHEE
;
Cheol Young PARK
;
Ki Won OH
;
Sung Woo PARK
;
Won Young LEE
Author Information
1. Division of Endocrinology, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Glucose tolerance test;
C-peptide;
Insulin secretion and incident diabetes
- MeSH:
C-Peptide;
Follow-Up Studies;
Glucose;
Glucose Tolerance Test;
Insulin;
Life Style;
Longitudinal Studies;
Prediabetic State;
Retrospective Studies;
ROC Curve
- From:Endocrinology and Metabolism
2016;31(2):320-327
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Diabetes can be efficiently prevented by life style modification and medical therapy. So, identification for high risk subjects for incident type 2 diabetes is important. The aim of this study is to identify the best β-cell function index to identify high risk subjects in non-diabetic Koreans. METHODS: This is a retrospective longitudinal study. Total 140 non-diabetic subjects who underwent standard 2-hour 75 g oral glucose tolerance test from January 2007 to February 2007 at Kangbuk Samsung Hospital and followed up for more than 1 year were analyzed (mean follow-up, 54.9±16.4 months). The subjects were consist of subjects with normal glucose tolerance (n=44) and subjects with prediabetes (n=97) who were 20 years of age or older. Samples for insulin and C-peptide levels were obtained at 0 and 30 minutes at baseline. RESULTS: Thirty subjects out of 140 subjects (21.4%) developed type 2 diabetes. When insulin-based index and C-peptide-based index are compared between progressor and non-progressor to diabetes, all C-peptide-based indices were statistically different between two groups, but only insulinogenic index and disposition index among insulin-based index were statistically different. C-peptide-based index had higher value of area under receiver operating characteristic curve (AROC) value than that of insulin-based index. "C-peptidogenic" index had highest AROC value among indices (AROC, 0.850; 95% confidence interval, 0.761 to 0.915). C-peptidogenic index had significantly higher AROC than insulinogenic index (0.850 vs. 0.731 respectively; P=0.014). CONCLUSION: C-peptide-based index was more closely related to incident type 2 diabetes in non-diabetic subjects than insulin-based index.
