Expression of Sialosyl-Tn Antigen in Breast Cancer & Its Correlation with Prognostic Parameters.
10.4048/jkbcs.1998.1.2.208
- Author:
Yong Tae KWON
1
;
Se Heon CHO
;
Young Hoon KIM
;
Sang Soon KIM
;
Sood Hee HONG
;
Jung Man KIM
;
Seok Reyol CHOI
Author Information
1. Department of General Surgery, Dong-A University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Sialosyl-Tn;
Breast Cancer;
Prognostic factors
- MeSH:
Breast Neoplasms*;
Breast*;
DNA;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Ploidies
- From:Journal of Korean Breast Cancer Society
1998;1(2):208-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To determine whether the expression of Sialosyl-Tn antigen may have its putative relationship as an established or potentially useful clinicopathologic prognostic parameter in breast cancer, we evaluated 110 patients with invasive breast carcinoma, using formalin-fixed, paraffin-embedded tissue sections. STn antigen was detected by the HB-STn antibody using an avidin-biotin-peroxidase method. The parameters studied were tumor size, nodal status, stage, histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. STn expression was observed in 42 patients (38.2%) with breast cancer. The expression rate of STn was associated with axillary node metastasis. A tendency towards an association between STn expression and tumor size or TNM stage. There was no relationship between STn expression and histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. We conclude that the detection of STn expression may be useful for predicting lymph node metastasis.
