Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery.
10.3349/ymj.2017.58.1.195
- Author:
Sung Hyun KIM
1
;
Se Hoon KIM
;
Hye Sung YOON
;
Hyun Kyoon KIM
;
Kyung Sik KIM
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. kskim88@yuhs.ac
- Publication Type:Original Article
- Keywords:
Animal model;
blood loss;
hemostatics;
histopathology;
oxidized regenerated cellulose
- MeSH:
Animals;
*Blood Loss, Surgical/statistics & numerical data;
Cellulose, Oxidized/*therapeutic use;
Hemostasis, Surgical/*methods;
Hemostatics/*therapeutic use;
Liver/*surgery;
Random Allocation;
Spleen/*surgery;
Swine
- From:Yonsei Medical Journal
2017;58(1):195-205
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Adequate hemostasis is important for postoperative outcomes of abdominal surgery. This study evaluated the hemostatic effects and accompanying histopathological changes of a novel oxidized regenerated cellulose, SurgiGuard®, during abdominal surgery. MATERIALS AND METHODS: Ten pigs underwent wedge resection of the spleen (1×1 cm) and liver (1.5×1.5 cm). The resected surface was covered with Surgicel® fabric or fibril type (Group A) or SurgiGuard® fabric or fibril type (Group B). Surgicel® and SurgiGuard® were randomized for attachment to the resected surface by fabric type (n=5) or fibril type (n=5). Blood loss was measured 5, 7, and 9 min after resection. Pigs were necropsied 6 weeks postoperatively to evaluate gross and histopathological changes. RESULTS: There was no significant difference in total blood loss between groups [spleen fabric: Group A vs. Group B, 4.38 g (2.74–6.43) vs. 3.41 g (2.46–4.65), p=0.436; spleen fibril: Group A vs. Group B, 3.44 g (2.82–6.07) vs. 3.60 g (2.03–6.09), p=0.971; liver fabric: Group A vs. Group B, 4.51 g (2.67–10.61) vs. 6.93 g (3.09–9.95), p=0.796; liver fibril: Group A vs. Group B, 3.32 g (2.50–8.78) vs. 3.70 g (2.32–5.84), p=0.971]. Histopathological analysis revealed no significant difference in toxicities related to Surgicel® or SurgiGuard® [inflammation, fibrosis, foreign bodies, and hemorrhage (spleen: p=0.333, 0.127, 0.751, and 1.000; liver: p=0.155, 0.751, 1.000, and 1.000, respectively)]. CONCLUSION: SurgiGuard® is as effective and non-toxic as Surgicel® in achieving hemostasis after porcine abdominal surgery.
