A Case of Recurrent Urticaria Due to Formaldehyde Release from Root-Canal Disinfectant.
10.3349/ymj.2017.58.1.252
- Author:
Ji Hoon JANG
1
;
Seung Hyun PARK
;
Hang Jea JANG
;
Sung Geun LEE
;
Jin Han PARK
;
Jae Won JEONG
;
Chan Sun PARK
Author Information
1. Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea. chansun@paik.ac.kr
- Publication Type:Case Reports
- Keywords:
Formaldehyde;
urticaria;
type 1 hypersensitivity
- MeSH:
Disinfectants/*adverse effects;
Formaldehyde/*adverse effects;
Humans;
Hypersensitivity, Immediate/*chemically induced;
Immunoglobulin E/*immunology;
Male;
Middle Aged;
Recurrence;
Skin Tests;
Time Factors;
Urticaria/*chemically induced/diagnosis;
Zinc Oxide-Eugenol Cement/*chemistry
- From:Yonsei Medical Journal
2017;58(1):252-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although formaldehyde is well known to cause type 4 hypersensitivity, immunoglobulin E (IgE)-mediated hypersensitivity to formaldehyde is rare. Here, we report a case of recurrent generalized urticaria after endodontic treatment using a para-formaldehyde (PFA)-containing root canal sealant and present a review of previous studies describing cases of immediate hypersensitivity reactions to formaldehyde. A 50-year-old man visited our allergy clinic for recurrent generalized urticaria several hours after endodontic treatment. Prick tests to latex, lidocaine, and formaldehyde showed negative reactions. However, swelling and redness at the prick site continued for several days. The level of formaldehyde-specific IgE was high (class 4). Thus, the patient was deemed to have experienced an IgE-mediated hypersensitivity reaction caused by the PFA used in the root canal disinfectant. Accordingly, we suggest that physicians should pay attention to type I hypersensitivity reactions to root canal disinfectants, even if the symptoms occur several hours after exposure.
