Hypersensitivity reaction to aspirin accompanied by severe eosinophilia in a child with history of Kawasaki disease.
10.4168/aard.2014.2.2.142
- Author:
In Suk SOL
1
;
Myung Hyun CHOI
;
Min Jung KIM
;
Yoon Hee KIM
;
Hee Seon LEE
;
Yoon Ki HAN
;
Ki Hwan KIM
;
Kyung Won KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics, Institute of Allergy, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea. kekim@yuhs.ac
- Publication Type:Case Report
- Keywords:
Eosinophilia;
Drug hypersensitivity reaction;
Aspirin;
Kawasaki disease
- MeSH:
Adult;
Anti-Inflammatory Agents, Non-Steroidal;
Aspirin*;
Child*;
Drug Hypersensitivity;
Eosinophilia*;
Humans;
Hypersensitivity*;
Immunoglobulins;
Infant;
Korea;
Leukocytosis;
Male;
Mortality;
Mucocutaneous Lymph Node Syndrome*;
Pharmacology;
Reye Syndrome
- From:Allergy, Asthma & Respiratory Disease
2014;2(2):142-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug hypersensitivity is one of drug adverse reactions that develop in susceptible patients following exposure to certain drugs and cannot be predicted from the known pharmacology of a drug. Severe hypersensitivity is associated with high morbidity and mortality. Although the issue of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has been largely investigated in adults, data related to NSAIDs hypersensitivity is insufficient in childhood. And in spite of the recommendation to avoid use of aspirin due to Reye syndrome in children, aspirin is one of major treatment along with intravenous immunoglobulin in Kawasaki disease. We report a case of a 10-month-old boy who underwent intravenous immunoglobulin and aspirin treatment for Kawasaki disease, and subsequently revealed severe leukocytosis and eosinophilia. To our knowledge, there have been no previous reports of aspirin-induced eosinophilia in Korea.
