The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes.
10.4093/kdj.2009.33.6.485
- Author:
Hyun Ae SEO
1
;
Yeon Kyung CHOI
;
Jae Han JEON
;
Jung Eun LEE
;
Ji Yun JEONG
;
Seong Su MOON
;
In Kyu LEE
;
Bo Wan KIM
;
Jung Guk KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jugkim@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Apolipoproteins;
Atherosclerosis;
Cardiovascular diseases;
Lipids;
Type 2 diabetes mellitus
- MeSH:
Apolipoprotein A-I;
Apolipoproteins;
Atherosclerosis;
Blood Pressure;
Body Height;
C-Peptide;
Calcium;
Cardiovascular Diseases;
Cause of Death;
Coronary Artery Disease;
Coronary Vessels;
Diabetes Mellitus, Type 2;
Female;
Humans;
Incidence;
Male;
Risk Factors
- From:Korean Diabetes Journal
2009;33(6):485-493
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. METHODS: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. RESULTS: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. CONCLUSION: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.
