The Effect of Agoraphobia on Oxidative Stress in Panic Disorder.
- Author:
Isil Gogcegoz GUL
1
;
Rifat KARLIDAG
;
Birgul Elbozan CUMURCU
;
Yusuf TURKOZ
;
Sukru KARTALCI
;
A Cemal OZCAN
;
M Erman ERDEMLI
Author Information
1. Uskudar University, Department of Psychiatry, Istanbul, Turkey. dr.isilggul@mynet
- Publication Type:Review
- Keywords:
Agoraphobia;
Free radical;
Panic disorder;
Oxidative stress;
Total antioxidant capacity
- MeSH:
Agoraphobia*;
Antioxidants;
Aryldialkylphosphatase;
Humans;
Malondialdehyde;
Oxidative Stress*;
Panic Disorder*;
Panic*
- From:Psychiatry Investigation
2013;10(4):317-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
