Neuromyeloencephalopathy Induced by Inadvertent Intrathecal Vincristine Injection.
- Author:
Don Soo KIM
1
;
Yong Duk KIM
;
Chul Woo RHYU
Author Information
1. Department of Neurology, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon, 302-718, Korea. drdonsoo@kyuh.co.kr
- Publication Type:Case Report
- Keywords:
Intrathecal vincristine;
Neuromyeloencephalopathy;
Acute lymphoblastic leukemia
- MeSH:
Central Nervous System;
Child;
Coma;
Female;
Fourth Ventricle;
Humans;
Persistent Vegetative State;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Vincristine*
- From:Journal of the Korean Neurological Association
2003;21(2):210-212
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Accidental intrathecal vincristine instillation is extremely toxic to the central nervous system. If given intrathecally, it produces a rapidly ascending, usually fatal, neuromyeloencephalopathy. This is a case where a 10-year-old girl received an inadvertent intrathecal administration of vincristine. The clinical course was rapidly progressive and resulted in comatose and vegetative state. Magnetic resornance image at post-injection 11 day showed high signal intensity lesion in cerebellar hemisphere and vermis adjacent to CSF passage third and fourth ventricle on T2 weighted images.
