Differential Expression of Hypoxia Inducible Factor-1 alpha and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas.
10.3346/jkms.2003.18.2.196
- Author:
Chang Hun LEE
1
;
Min Ki LEE
;
Chi Duk KANG
;
Young Dae KIM
;
Do Youn PARK
;
Jee Yeon KIM
;
Mee Young SOL
;
Kang Suek SUH
Author Information
1. Department of Pathology, College of Medicine, Pusan National University, Busan, Korea. cnlee@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, Non-Small Cell Lung;
Hypoxia-inducible Factor-1;
Endothelial Growth Fac-tors;
Antigens, CD34;
Proliferating Cell Nuclear Antigen;
Immunohistochemistry
- MeSH:
Adenocarcinoma/metabolism*;
Adenocarcinoma/pathology;
Animals;
Antigens, CD34/metabolism;
Carcinoma, Non-Small-Cell Lung/metabolism*;
Carcinoma, Non-Small-Cell Lung/pathology;
Carcinoma, Non-Small-Cell Lung/surgery;
Carcinoma, Squamous Cell/metabolism*;
Carcinoma, Squamous Cell/pathology;
Cell Division/physiology*;
Human;
Immunohistochemistry;
Proliferating Cell Nuclear Antigen/metabolism;
Survival Rate;
Transcription Factors/metabolism*;
Vascular Endothelial Growth Factor A/metabolism
- From:Journal of Korean Medical Science
2003;18(2):196-203
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1 alpha (HIF-1 alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell lung carcinomas (NSCLCs). We performed immunohistochemical stains using paraffin-embedded tissue blocks from 84 cases of operable NSCLC [No. of squamous cell carcinoma (SCC), 45; No. of adenocarcinoma (AC), 39]. HIF-1 alpha expression was related with histologic types (66.7% in SCCs vs 20.5% in ACs, p<0.001), but not with lymph node status, tumor stage, vascular endothelial growth factor expression, microvessel density (MVD), and proliferating cell nuclear antigen (PCNA) index (p>0.05, respectively). As for the histologic types, MVD and PCNA index were significantly higher in SCCs than in ACs (p=0.009 and p=0.016, respectively). Among HIF-1 alpha positive carcinomas, MVD was significantly higher in HIF-1 alpha positive SCCs than in HIF-1 alpha positive ACs (p=0.023). The overall survival curves were not associated with HIF-1 alpha expression or any other histologic parameters (p>0.05). These findings suggest that HIF-1 alpha expression in NSCLCs may play a differential role according to histologic types, but its prognostic significance is indeterminate.
