Some opinions of the clinical progress of the patients with chronic granular leukemia
- Author:
Thanh Ha Nguyen
- Publication Type:Journal Article
- Keywords:
leukemia
- MeSH:
Leukemia;
Hydroxyurea
- From:Journal of Practical Medicine
2002;435(11):46-48
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The aim of this study is to examine the effectiveness of hydroxyurea in treating CML patients in chronic phase. The result of the research shows that the induction treatment with hydroxyurea (initial dose: 40-60mg/kg body weight daily) radically improved clinical condition for CML patients: the size of spleen was reduced in the majority of patients (91.7% and 63.9% patients have palpable spleen (P<0.05), 83.3% and 5.6% patients have enlarged spleen third and forth degree before and after induction treatment respectively, percentage of patients with symptoms of high viscosity syndrome decreased from 36.1% to 0% after treatment with P<0.001, symptoms of anemia were decreased in the majority of patients. The follow up during the time of induction treatment shows that main clinical symptoms (enlarged spleen, high viscosity syndrome, anemia) have improved gradually in accordance with the decrease of WBC
