HLA Antigens, T and B Lymphocytes and other Associated Laboratory Findings in Patients with Vitiligo.
- Author:
Yoon Kee PARK
;
Min Geol LEE
;
Jin Soo KANG
;
Won Hyong KANG
- Publication Type:Original Article
- MeSH:
Anemia;
B-Lymphocytes*;
Diabetes Mellitus;
HLA Antigens*;
Humans;
Immunoglobulin A;
Immunoglobulin G;
Immunoglobulin M;
Immunologic Factors;
Lymphocytes;
Mass Screening;
Phenotype;
T-Lymphocytes;
Thyroid Diseases;
Urinalysis;
Vitiligo*
- From:Korean Journal of Dermatology
1984;22(5):461-466
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although vitiligo is a common disorder with well-known clinical features, its etiology is still vague. It has been suggested that immunologic factors are important in the pathophysiology of vitiligo. And the association of HLA antigens with vitiligo has been reported. Authors examined HLA phenotypes in thirty-nine patients, T lymphocytes in thirty- three patients, B lymphocytes in thirty-one patients, and quantitation of IgG, IgA, IgM and IEP(immunoelectrophoresis) in twenty-five patients with vitiligo in this study. T3 and T4 were investigated in twelve patients, CBC in thirty-nine and urinalysis in thirty-five patients with vitiligo for screening of associated diseases ; thyroid disease, anemia and diabetes mellitus. The results are as follows; The frequency of HLA A9, Bw15 and Bw22 was significantly decreased in vitiligo patients compared to control group(p=0. 003, 0. 02, 0. OR) 2. There were no significant differences in the results of total and active lymphocytes and B lymphocytes in vitiligo patients compared to the control group. The results of quantitation of IgG, IgA, IgM and IEP showed within normal lirnits except one, an increased IgG, 2,200rng/100ml (normal: 500 1,500) and polyclonal gammopathy. 4. Among twelve vitiligo patients, one showed increased TR, 355ng/100ml (normal: 80 220) and T4, 17. 3pg/100ml (normal: 5 13). 5. CBC and urinalysis were within normal limits in all patients.
