Effects of UVB on the Induction and Elicitation of DNCB Contact Sensitivity in Guinea Pigs.
- Author:
Eun Jung CHUNG
;
Shi Ryong CHOI
;
Chung Won KIM
;
Won HOUH
- Publication Type:Original Article
- MeSH:
Animals;
Dermatitis, Contact*;
Dinitrochlorobenzene*;
Guinea Pigs*;
Guinea*
- From:Korean Journal of Dermatology
1984;22(5):502-508
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aims of study presented here were to determine dose-dependent effects of UVB irradiation on CHS reaction and comparative effects of VVB on the induction and elicitation in guinea pigs. Pre-induction exposure to either suberythemal or supraerythemal doses of UVB resulted in suppreasion of CHS (53.47% & 57.64%) campared to positive control (79. 86%) However, suberythemal doses of UVB generated a more potent suppression than supraerythemal doses. Pre-elicitation exposure to suberythemal doses of UVB on the elicitation sites and adjacent to elicitation sites resulted in suppressed CHS reactions in both groups (60.4zg & 56.25p,). When the reaction by UVB was eliminated from the cutaneous reaction elicited in guinea pigs sensitized to DNCB, by UVB irradiation on the adjacent to elicitation sites, generated a more potent suppression than that UVB was directly irradiated on the elicitation sites.
