Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.
10.5115/acb.2012.45.3.170
- Author:
Mahsa TARAMESHLOO
1
;
Mohsen NOROUZIAN
;
Saeed ZAREIN-DOLAB
;
Masoomeh DADPAY
;
Jaleh MOHSENIFAR
;
Roohollah GAZOR
Author Information
1. Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.taramoshlou@sbmu.ac.ir
- Publication Type:Original Article
- Keywords:
Wound healing;
Aloe;
Thyroid hormones;
Silver sulfadiazine;
Wistar rats
- MeSH:
Administration, Topical;
Aloe;
Animals;
Blood Vessels;
Dermis;
Epithelium;
Fibroblasts;
Glycosaminoglycans;
Humans;
Macrophages;
Male;
Neutrophils;
Rats;
Rats, Wistar;
Re-Epithelialization;
Silver Sulfadiazine;
Thyroid Gland;
Thyroid Hormones;
Wound Healing
- From:Anatomy & Cell Biology
2012;45(3):170-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P< or =0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.
