A case of Cushing's syndrome in ACTH-secreting mediastinal paraganglioma.
- Author:
Hyeong Kwan PARK
1
;
Chang Min PARK
;
Kyung Heng KO
;
Myung Soo RIM
;
Yu Il KIM
;
Jun Hwa HWANG
;
Sung Chul IM
;
Yung Chul KIM
;
Kyung Ok PARK
Author Information
1. Pulmonary Department of Internal Medicine, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Case Report
- Keywords:
Cushing's syndrome;
ACTH;
Mediastinum;
Paraganglioma
- MeSH:
Case Report;
Corticotropin/secretion+ACo-;
Cushing Syndrome/etiology+ACo-;
Female;
Human;
Mediastinal Neoplasms/therapy;
Mediastinal Neoplasms/secretion;
Mediastinal Neoplasms/complications+ACo-;
Middle Age;
Paraganglioma, Extra-Adrenal/therapy;
Paraganglioma, Extra-Adrenal/secretion;
Paraganglioma, Extra-Adrenal/complications+ACo-
- From:The Korean Journal of Internal Medicine
2000;15(2):142-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
Paragangliomas are unusual neuroendocrine cell tumors arising from paraganglia, of which ACTH-secreting cases in the mediastinum are extremely rare. A 51-year-old woman was admitted for generalized edema and weakness which began 5 months ago. Chest X-ray and CT scan revealed a tumor mass in the anterior mediastinum. The plasma cortisol and ACTH levels were very high. Other sources secreting ACTH, except mediastinal mass, were not found. Surgical excision of mediastinal mass and left supraclavicular lymph node was performed. The postoperative microscopic finding and immunohistochemical staining revealed organoid tumor cell nests (zellballen) and S-100 protein positive sustentacular cells which are characteristics of paraganglioma. This was thus a case of Cushing's syndrome resulting from ectopic ACTH production in anterior mediastinal paraganglioma.
