Is additional acid-suppressing agents needed after the initial Helicobacter pylori eradication therapy to heal peptic ulcers?.
- Author:
Jae Jin JUNG
1
;
Dong Wook LEE
;
Dong Su LEE
;
Kang Wook CHUNG
;
Young Sung KIM
;
Eun Young KIM
;
Soo Ho SON
;
Jun Ki YEO
;
Dong Hyup KWAK
Author Information
1. Department of Internal Medicine, Kwak's Hospital, Taegu, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Helicobacter pylori;
Peptic ulcer
- MeSH:
Amoxicillin;
Clarithromycin;
Duodenal Ulcer;
Endoscopy;
Helicobacter pylori*;
Helicobacter*;
Humans;
Omeprazole;
Peptic Ulcer*;
Ulcer
- From:Korean Journal of Medicine
2001;60(5):439-443
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Helicobacter pylori (H. pylori) can now be eradicated in the majority of patients with 7 days of treatment with OAC (omeprazole+amoxicillin+clarithromycin) regimen. It is unclear if additional acid-suppressing treatment should be continued beyond 7 days in patients with active gastric or duodenal ulcers. METHODS: Ninety two patients with endoscopically proven active peptic ulcers who were H. pylori positive were randomized to receive either omeprazole 20 mg plus amoxicillin 1.0g plus clarithromycin 500mg ; twice daily for 1 week alone (OAC group) or same regimen followed by 3 weeks of omeprazole (OACP group). Endoscopy and UBT (urea breath test) were performed 8 weeks after the initiation of treatment. RESULTS: Forty four of forty five (97.8%) of OAC group and forty four of forty seven (93.6%) of OACP group were noted to have healed ulcer at week 8. CONCLUSION: In patients with H. pylori infection and peptic ulcers, one week of OAC therapy without further need for PPI may heal the ulcers. Following an l week course of H. pylori eradication therapy by OAC for peptic ulcers, further 3 weeks of acid-suppressing therapy with PPI was not proven to promote ulcer healing rate.
