Effectiveness of Ondansetron and Midazolam in the Prevention of PONV after Thyroidectomy.
10.4097/kjae.2007.53.3.344
- Author:
Jae Hyun HA
1
;
Kyung Hwa KWAK
;
Jeong Won SEO
;
Su Hyun LEE
;
Sung Sik PARK
;
Woon Ei BAEK
Author Information
1. Department of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine, Deagu, Korea. hwakkh@hotmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
antiemetic;
ondansetron;
midazolam;
postoperative nausea and vomiting (PONV);
thyroidectomy
- MeSH:
Anesthesia, General;
Female;
Humans;
Incidence;
Midazolam*;
Nausea;
Ondansetron*;
Postoperative Nausea and Vomiting*;
Thyroidectomy*;
Vomiting
- From:Korean Journal of Anesthesiology
2007;53(3):344-349
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to investigate the effectiveness of ondansetron and midazolam in the prevention of PONV after thyroidectomy. METHODS: One hundred nineteen women undergoing thyroidectomy under general anesthesia were randomized to receive midazolam 0.075 mg/kg (Group M, n = 41), ondansetron 4 mg (Group O, n = 39), or normal saline 10 ml (Group C, n = 39) intravenously. The incidence and severity of nausea, vomiting, and pain were assessed as 6 and 24 h after the end of surgery. RESULTS: The incidence of PONV was 34% in Group M, 46% in Group O, and 64% in Group C, which showed a significant difference between Group C and Group M, but not Group O. However, there were no significant differences between groups in pain scores and the incidence of sedation. CONCLUSIONS: We recommend the use of midazolam as an effective antiemetic after thyroidectomy.
