The healing effect of rhGM - CSF on uninfected wounds.
- Author:
Seung Kyu HAN
1
;
Byung Soo KIM
;
Ae Ree KIM
;
Jae Hong SEO
;
Chul Won CHOI
;
Sang Won SHIN
;
Yeul Hong KIM
;
Woo Kyung KIM
;
Jun Suk KIM
Author Information
- Publication Type:Original Article
- Keywords: rhGM - CSF; uninfected wound healing
- MeSH: Animals; Bandages; Endothelial Cells; Keratinocytes; Mice; Random Allocation; Rats, Sprague-Dawley; Water; Wound Healing; Wounds and Injuries*
- From:Immune Network 2001;1(1):32-35
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing on the uninfected wounds. METHODS: Thirty Sprague-dawley white mice(250-300g) were selected in this study . The number of wound with the diameter of 5 mm, was 3 in left and 3 in right at the symmetric sites, respectively . The site of rhGM-CSF dressing was decided by a randomization. rhGM-CSF(Leucogen (r)) was diluted in the distilled water(5 micro gram/mL). The experimental wound group was dressed by l mL of distilled water mixed with rhGM-CSF and control wound group was dressed by l mL of distilled water. The dressing was done, every 24 hours. The criteria of comparison were the duration of wound healing duration, histologic findings and the bacterial culture of wound sites. RESULTS: The duration of wound healing was 10.3+/-1.7 days in experimental group and 10.2+/-2.8 days in control group, without significant difference. There was no specific difference of histologic findings between both groups. The pathogen was not found, at all. CONCLUSION: It seems to be that rhGM-CSF has no prominent effect on the uninfected wound healing in the mice without immune suppression.
