Plasmafiltration and Synchronized cyclophosphamide therapy in SLE with aplastic anemia.
- Author:
Jee Won PARK
1
;
So Yeon CHOI
;
Hyun Soo KIM
;
Dong Ki NAM
;
Hugh Chul KIM
;
Hee Yeon KIM
;
Hae Sim PARK
;
Dong Ho NAHM
Author Information
1. Department of Allergy and clinical immunology, School of Medicine, Su-won, Korea.
- Publication Type:Case Report
- MeSH:
Adult;
Anemia, Aplastic*;
Autoimmune Diseases;
Biopsy;
Bone Marrow;
Cyclophosphamide*;
Female;
Filtration;
Gingiva;
Hemorrhage;
Humans;
Nephrotic Syndrome;
Plasma
- From:Korean Journal of Medicine
1999;56(1):129-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Systemic lupus erythematosus(SLE) is a multisystemic autoimmune disease. In rare case, aplastic anemia can develop as a complication of SLE. We report a case of SLE patient with aplastic anemia and nephrotic syndrome. A 33-year-old woman was admitted because of gum bleeding. After laboratory work up including bone marrow biopsy study, she was diagnosed as SLE with aplastic anemia and nephrotic syndrome. The patient was initially treated with high dose steroid pulse therapy. However the patient did not responded to high dose steroid treatment. We treated the patient with plasma filtration and synchronized cyclophosphamide thrapy followed by monthly intravenous cyclophosphamide treatment. Complete clinical remission of hematologic and renal complications was achieved in this patient. We suggest that plasma filtration and synchronized cyclophosphamide therapy might be one of efffectie treatment modality in the management of severe SLE patient.
