Successful treatment with ganciclovir for cytomegalovirus duodenitis following allogenic bone marrow transplantation.
- Author:
Jin Hee AHN
1
;
Je Hwan LEE
;
Kyoo Hyung LEE
;
Woo Kun KIM
;
Jung Shin LEE
;
Hyeseung BAHNG
;
Hwoon Yong JUNG
;
Yang Soo KIM
;
Onja KIM
;
Sang Hee KIM
Author Information
1. Departments of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Cytomegalovirus(CMV);
BMT;
Ganciclovir
- MeSH:
Adult;
Antiviral Agents/therapeutic use*;
Bone Marrow Transplantation/adverse effects;
Case Report;
Cytomegalovirus Infections/etiology;
Cytomegalovirus Infections/drug therapy*;
Cytomegalovirus Infections/diagnosis;
Duodenitis/etiology;
Duodenitis/drug therapy*;
Duodenitis/diagnosis;
Ganciclovir/therapeutic use*;
Human;
Male;
Transplantation, Homologous
- From:The Korean Journal of Internal Medicine
1999;14(1):91-94
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cytomegalovirus(CMV) disease is a major cause of morbidity and mortality in immunocompromised patients. CMV enteritis should be considered when nausea and vomiting continue 3 to 4 weeks after bone marrow transplantation(BMT). The treatment of CMV enteritis is not well established. We report a CMV duodenitis patient following allogenic bone marrow transplantation. The patient had prolonged nausea and vomiting for 5 weeks after bone marrow transplantation and CMV duodenitis was diagnosed by the gastroduodenoscopic mucosal biopsy which showed cytomegalic cells. Ganciclovir treatment for 3 weeks resulted in the resolution of symptoms and promoted healing of the lesion. The patient was free of CMV infection until 288 days after allogenic BMT without maintenance ganciclovir treatment.