Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation.
10.3344/kjp.2016.29.3.172
- Author:
Alireza Amir MAAFI
1
;
Banafsheh GHAVIDEL-PARSA
;
Afrooz HAGHDOOST
;
Yasaman AARABI
;
Asghar HAJIABBASI
;
Irandokht SHENAVAR MASOOLEH
;
Habib ZAYENI
;
Babak GHALEBAGHI
;
Amir HASSANKHANI
;
Ali BIDARI
Author Information
1. Student Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
- Publication Type:Original Article
- Keywords:
Chronic pain syndrome;
Fibromyalgia;
Invalidation;
Iran;
Surveys and Questionnaires;
Vitamin D
- MeSH:
Fibromyalgia*;
Health Surveys;
Humans;
Iran;
Logistic Models;
Spouses;
Surveys and Questionnaires;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:The Korean Journal of Pain
2016;29(3):172-178
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences. METHODS: A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman's correlations were calculated. RESULTS: 88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient's spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95-19.87, P = 0.05). CONCLUSIONS: This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient's spouse is important in management of FM.
