A Case of Mesangial IgM Nephropathy without Proteinuria.
- Author:
Kang Hyu LEE
1
;
Kyung Pyo KANG
;
Won KIM
;
Myung Jae KANG
;
Seong Kwang PARK
;
Sung Kyew KANG
Author Information
1. Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea. hope@moak.chonbuk.ac.kr
- Publication Type:Case Report
- Keywords:
IgM nephorpathy;
Hematuria without proteinuria
- MeSH:
Antibodies, Antinuclear;
Biopsy;
Cell Proliferation;
Complement System Proteins;
Erythrocytes;
Female;
Fluorescent Antibody Technique;
Foot;
Hematuria;
Humans;
Immunoglobulin M*;
Mesangial Cells;
Microscopy, Electron;
Middle Aged;
Proteinuria*
- From:Korean Journal of Nephrology
2002;21(2):317-321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An 51-year-old woman presented with microscopic hematuria without protenuria for long time. Laboratory studies demonstrated the presence of red blood cells in urine, a normal serum IgM level, the absence of antinuclear antibodies, and a normal complement level. Renal biopsy revealed that some glomeruli are enlarged with endocapillary cell proliferation and a few glomeruli exhibit prominent vascular pole of the tufts and segmental increase in mesangial cell and matrix. Immunofluorescence studies demonstrated segmental granular deposits for IgM. Electron microscopy showed well-preserved foot process associated with focal effacement. Biopsy findings were consistent with IgM nephropathy. We present this case to promote understanding of the pathogenesis of IgM nephropathy.
