Melanosis coli--histochemical and immunohistochemical comparison of the pigments of melanosis coli and Dubin-Johnson syndrome.
- Author:
Chanil PARK
1
;
Nam Hoon CHO
;
Hyeon Joo JEONG
Author Information
- Publication Type:Case Reports ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: Melanosis coli; melanin; lipofuscin; melanin-like pigment; Dubin-Johnson syndrome
- MeSH: Case Report; Colonic Diseases/*metabolism; Comparative Study; Histocytochemistry; Human; Immunohistochemistry; Jaundice, Chronic Idiopathic/*metabolism; Male; Melanosis/*metabolism; Middle Age; Pigments/*metabolism; Support, Non-U.S. Gov't
- From:Yonsei Medical Journal 1990;31(1):27-32
- CountryRepublic of Korea
- Language:English
- Abstract: We compared the pigment of melanosis coli with the pigment of Dubin-Johnson syndrome, melanin, and lipofuscin. The pigment of melanosis coli appeared similar to lipofuscin in that it stained positively with periodic acid-Schiff, oil red-0 and Victoria blue stains and revealed negative reactions to the immunohistochemical stains for S-100 protein and neuron specific enolase, but had similarity to melanin as shown by the positive reaction to Fontana-Masson stain and negative autofluorescence. The pigment of Dubin-Johnson syndrome showed the same histochemical and immunohistochemical characteristics as that of melanosis coli. The results indicate that the pigments of melanosis coli and Dubin-Johnson syndrome are identical and are variants of lipofuscin.
