Pathologic Changes in the Rabbit lung Following Single Dose irradiation.
- Author:
Hyung Sik LEE
1
;
Young Min CHOI
;
Won Joo HUR
;
Jin Sook JEONG
;
Young Hyun YUH
;
Ki Nam LEE
Author Information
1. Department of Radiation Oncology, Dong-A University, College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Radiation pneumonitis;
fibrosis;
rabbit
- MeSH:
Animals;
Capillaries;
Fibrosis;
Lung*;
Pneumocytes;
Rabbits;
Radiation Pneumonitis
- From:Journal of the Korean Society for Therapeutic Radiology
1994;12(2):143-150
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group were sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation, and they progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type II pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.
