The Effects of Dexamethasone on Blood Pressure in Premature Infants with Bronchopulmonary Dysplasia.
- Author:
Hyung Chul CHOI
1
;
So Ra LEE
;
Hwa In KIM
;
Yeon Kyun OH
Author Information
1. Department of Pediatrics, College of Medicine, Wonkwang University, Iksan, Korea.
- Publication Type:Original Article
- Keywords:
Dexamethasone;
Blood pressure;
Bronchopulmonary dysplasia;
Prematurity
- MeSH:
Birth Weight;
Blood Pressure*;
Bronchopulmonary Dysplasia*;
Dexamethasone*;
Gestational Age;
Humans;
Infant;
Infant, Newborn;
Infant, Premature*;
Retrospective Studies;
Turkey
- From:Journal of the Korean Society of Neonatology
1999;6(1):16-23
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effects of dexamethasone(D) on blood pressure(BP) in infants with bronchopulmonary dysplasia(BPD). METHODS: We retrospectively reviewed 10 infants with BPD(mean birth weight: 1,383+/-17 gm, mean gestational age: 29.0+/-1.7 weeks) treated with D at Wonkwang University Hospital from January 1994 to June 1998. D was started at 0.5 mg/kg/day intravenously for first week, followed by 0.3 and 0.1 mg/kg/day for second and third week, respectively. Changes in BP during pre-D, 1st wk(D1), 2ndwk(D2), 3rd wk(D3), and post-D periods were compared using Turkey Kramer multiple comparison test. RESULTS: Mean systolic pressure(sBP) significantly increased in Dl, D2, D3 compared to pre-D(63+1.3, P<0.01; 66+1.7, P<0.001; 683.4, P<0.001 vs 591.9 mmHg, respectively) but significantly decreased in post-D compared to D3(64+/-2.4 mmHg, P<0.05). Mean diastolic pressure(dBP) significantly increased in D2 and D3 compared to pre-D(42+/-1.1, P<0.001; 43+/-2.6, P<0.001, vs 382.1 mmHg, respectively). Mean dBP deed slightly in post-D(41+/-4.1 mrnHg, P>0.05). The sBP and dBP significantly increased from day 2 after initiation of D and were highest on day 17 and 17-18 of 3rd week, respectively. The number of hypertensive infants who were considered for antihypertensive medications were 2(20%) for sBP >or= 80-90 mmHg, 3(30%) for dBP >or= 50 mmHg and 1(10%) for dBP> or =60 mmHg. These infants, however, remained asymptomatic. CONCLUSION: Significant elevation of BP was observed during dexamethasone therapy for infants with BPD especially after 2nd day. However, BP elevation was transient, not requiring antihypertensive medications.
