Clinical Features and Neurologic Complications of Pediatric Enteroviral Meningitis.
10.26815/jkcns.2017.25.4.246
- Author:
Seo Yeol CHOI
1
;
Young Seok LEE
;
Jeesuk YU
Author Information
1. Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea. dryujs@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Enterovirus;
Meningitis;
Pleocytosis;
Complication
- MeSH:
Body Temperature;
Cerebrospinal Fluid;
Child;
Diagnosis;
Enterovirus;
Fever;
Glucose;
Headache;
Humans;
Leukocytes;
Leukocytosis;
Male;
Medical Records;
Meningitis*;
Meningoencephalitis;
Polymerase Chain Reaction;
Retrospective Studies;
Reverse Transcription;
Risk Factors;
Seasons;
Seizures;
Status Epilepticus
- From:
Journal of the Korean Child Neurology Society
2017;25(4):246-254
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To explore clinical features and neurologic complications of pediatric enteroviral meningitis, and to evaluate risk factors according to the presence of cerebrospinal fluid (CSF) pleocytosis and neurologic complications. METHODS: Retrospective review of medical records of patients aged between 1 month and 18 years who were found positive for CSF enterovirus reverse transcription polymerase chain reaction in Dankook University Hospital from March 2009 to February 2015. RESULTS: A total of 151 children was enrolled in the study. Ninety four patients were males and the age at diagnosis was 40.9±47.0 months. Most common season of admission was summer (n=99, 65.6%). Most frequent presenting symptom was fever followed by poor oral intake, decreased activity, and headache. Fifty five (36.4%) patients had no CSF pleocytosis. Complications were observed in 4 (2.6%). Mean blood white blood cell, CSF protein levels were higher, and CSF glucose levels were lower in group with pleocytosis (P < 0.05). There were more seizure development and mental changes, higher peak body temperature, longer fever duration, and longer duration from symptom onset to CSF tapping in group with complications (P < 0.05). All were boys and mean age at admission was younger in group with complications, without statistically significant difference. CONCLUSION: Relatively high proportion of children with enteroviral meningitis showed no pleocytosis. Complications such as meningoencephalitis, refractory status epilepticus, or recurrent seizure rarely occurred, although most had good clinical outcomes.
