The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants.
- Author:
Heui seung JO
1
;
Beyong Il KIM
;
Chang Won CHOI
;
Jun Dong PARK
;
Chong Jai KIM
;
Jung Hwan CHOI
Author Information
1. Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea. beyil@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Histologic chorioamnionitis;
Respiratory distress syndrome;
Chronic lung disease;
Preterm infants
- MeSH:
Birth Weight;
Chorioamnionitis*;
Female;
Humans;
Incidence;
Infant, Newborn;
Infant, Premature*;
Intensive Care, Neonatal;
Lung Diseases*;
Lung*;
Pregnancy;
Premature Birth;
Retrospective Studies;
Risk Factors;
Seoul
- From:Korean Journal of Pediatrics
2004;47(2):150-156
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants. METHODS: Clinical data were collected retrospectively from 478 preterm infants(gestational period< or =34 weeks) who were admitted to the neonatal intensive care unit(NICU) in Seoul National University Children's Hospital from January 1993 to December 2000. RESULTS: Histologic chorioamnionitis(CA) was observed in 210 of 478 infants(44%). Lower gestational period was detected in CA(+) group(31+1 +/- 2+2 weeks vs. 30+1+/-2+3 weeks). CA(+) group had decreased incidence of RDS(38.4% vs. 28.1%)[odds ratio, OR 0.35(P=0.0004, 95% confidence intervals, CI 0.19-0.63)], and increased incidence of CLD(7.5% vs. 13.3%)[OR 1.95(P=0.047, 95% CI 1.01-3.79)] combined much more "atypical CLD"(10.5% vs. 55.6%). CA(+) group had decreased incidence of patent ductus arteriosus(33.3% vs. 25.4%)[OR 0.37(P=0.003, 95% CI 0.19-0.71)]. There was no difference between the two groups in birth weight. CONCLUSION: It is suggested that intrauterine infections and fetal inflammatory responses might play a role in the outcome of preterm infants, and histologic chorioamnionitis is an isolated risk factor in the development of RDS and CLD of the preterm infants.
