Serum ECP, RANTES and Eotaxin Levels in Infants with Bronchiolitis.
- Author:
Jong Seo YOON
1
;
Mi Hee LEE
;
Joon Sung LEE
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. jslee@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Bronchiolitis;
Respiratory syncytial virus;
Eosinophil cationic protein;
Regulated on activation normal T-cell expressed and secreted;
Eotaxin
- MeSH:
Asthma;
Bronchiolitis*;
Chemokine CCL5*;
Eosinophil Cationic Protein;
Eosinophils;
Humans;
Immunoenzyme Techniques;
Immunoglobulin E;
Immunoglobulins;
Infant*;
Inflammation;
Respiratory Syncytial Viruses;
T-Lymphocytes;
Virus Diseases
- From:Korean Journal of Pediatrics
2004;47(2):170-176
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Viral respiratory infection, especially respiratory syncytial(RS) virus, can predispose sufferers to the development of asthma by mechanisms that are presently undetermined. The role of inflammatory mediators in pathogenesis of asthma and RS virus disease is not well-understood. We investigated the performance of serum eosinophil cationic protein(ECP), regulated on activation normal T-cell expressed and secreted(RANTES) and eotaxin levels on the airway inflammation in a population of patients with RS virus and non-RS virus bronchiolitis, compared with control subjects. METHODS: Twenty-eight patients with RS virus positive bronchiolits, 11 patients with RS virus negative bronchiolitis and seven control subjects were enrolled in the study. Serum ECP, RANTES and eotaxin levels were measured by enzyme immunoassay. We analyzed the correlation among serum ECP, RANTES, eotaxin, immunoglobulin E and blood eosinophil count in the RS virus positive bronchiolitis group and the RS virus negative bronchiolitis group, respectively. RESULTS: Both serum ECP and RANTES in the brochiolitis group were not higher than in the control. Serum eotaxin concentration in bronchiolitis group was significantly higher than in control(P= 0.030), but there was no significant difference between RS virus positive and negative groups. There were significant correlations between the peripheral blood eosinophil count and serum ECP, and between the levels of serum ECP and RANTES in the RS virus positive bronchiolitis group(P=0.038, 0.012 respectively). CONCLUSION: Serum eotaxin may have a systemic effect in pathophysiology of bronchiolitis but ECP and RANTES may not. However, they may have some indirect effects inferred from the correlations among them.
