Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of Intervertebral Disc Degeneration Susceptibility: Meta-Analysis.
10.4184/asj.2016.10.5.964
- Author:
Luming NONG
1
;
Yongjing HUANG
;
Shujie ZHAO
;
Nanwei XU
Author Information
1. Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, Changzhou, China. 18351229571@163.com
- Publication Type:Meta-Analysis ; Review
- Keywords:
Vitamin D receptor;
Matrix metalloproteinase-3;
Polymorphism;
Meta-analysis
- MeSH:
Intervertebral Disc Degeneration*;
Intervertebral Disc*;
Matrix Metalloproteinase 3*;
Odds Ratio;
Receptors, Calcitriol*;
Risk Factors;
Vitamin D*;
Vitamins*
- From:Asian Spine Journal
2016;10(5):964-971
- CountryRepublic of Korea
- Language:English
-
Abstract:
Several studies have evaluated the association between vitamin D receptor, matrix metalloproteinase 3 (MMP-3) polymorphisms and the risk of intervertebral disc degeneration susceptibility. The findings were inconsistent. This meta-analysis aimed to systematically assess the association between vitamin D receptor, MMP-3 polymorphisms and the risk of intervertebral disc degeneration susceptibility. A search of various databases was done covering all papers published until December 31th, 2014. Eight, 4, 3 studies were finally included that addressed the risk of intervertebral disc degeneration susceptibility and vitamin D receptor FokI (rs2228570), ApaI (rs7975232), and MMP-3 (rs731236) polymorphisms, respectively. FokI (f vs. F: summary odds ratio [OR], 1.13; 95% confidence interval [CI], 0.76–1.69; ff vs. FF: OR, 1.02; 95% CI, 0.59–1.77; ff vs. Ff/FF: OR, 1.05; 95% CI, 0.70–1.58), ApaI (a vs. A: OR, 0.73; 95% CI, 0.45–1.19; aa vs. AA: OR, 0.53; 95% CI, 0.22–1.25 p=0.14; aa vs. AA/Aa: OR, 0.69; 95% CI, 0.53–0.89) in the vitamin D receptor gene and MMP3 polymorphisms (5A vs. 6A: OR, 1.92; 95% CI, 0.77–4.80; 5A5A vs. 6A6A: OR, 2.17; 95% CI, 0.75–6.24; 5A5A vs. 5A6A/6A6A: OR, 1.58; 95% CI, 0.72–3.44) were not obviously associated with risk of intervertebral disc degeneration susceptibility. FokI, ApaI polymorphisms in the vitamin D receptor gene and MMP-3 polymorphism are not obvious risk factors for intervertebral disc degeneration susceptibility.
