Prevalence of autoantibodies in sera from atopic and non-atopic asthmatics.
- Author:
Dong Ho NAHM
1
;
Sun Sin KIM
;
Soo Keol LEE
;
Hae Sim PARK
Author Information
1. Departement of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
Bronchial asthma;
Autoantibodies;
Atopy;
Non-atopy
- MeSH:
Allergens;
Antibodies, Antinuclear;
Asthma;
Autoantibodies*;
Fluorescent Antibody Technique, Indirect;
Healthy Volunteers;
Humans;
Immunoglobulin E;
Immunoglobulin G;
Iodide Peroxidase;
Lupus Erythematosus, Systemic;
Prevalence*;
Radioimmunoassay;
Skin;
Thyroglobulin;
Thyroid Gland
- From:Journal of Asthma, Allergy and Clinical Immunology
2000;20(2):229-235
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: There have been several reports showing increased prevalences of various autoantibodies in non-atopic asthma compared to atopic asthma. And the possible involvement of autoimmune mechanisms in the pathogenesis of non-atopic asthma has been suggested. To evaluate this hypothesis, we compared the prevalence of circulating autoantibodies in sera from patients with non-atopic and atopic asthma. SUBJECTS AND METHODS: Serum samples from 23 patients with non-atopic asthma showing no visible skin reaction to 50 common inhalant allergens and serum total IgE levels below 200 IU/ml, 23 patients with atopic asthma who showing positive skin prick tests and positive allergen bronchoprovocation tests, 34 age-matched healthy volunteers, and 20 patients with systemic lupus erythematosus were enrolled. We screened IgG antinuclear antibody by indirect immunofluorescence test using HEp-2 cell, and IgG autoantibodies to thyroglobulin and thyroid peroxidase by radioimmunoassay. RESULTS: IgG antinuclear antibodies were found in 1 (3%) of 34 healthy volunteers, 3 (13%) of 23 patients with non-atopic asthma, none of 23 patients with atopic asthma, 19 (95%) of 20 patients with systemic lupus erythematosus. IgG autoantibodies to thyroglobulin or thyroid peroxidase were found in 2 (6%) of 34 healthy volunteers, 2 (9%) of 23 patients with non-atopic asthma, 1 (4%) of 23 patients with atopic asthma, and 4 (25%) of 20 patients with systemic lupus erythematosus. CONCLUSION: There was no evidence for increased prevalence of autoantibodies to nuclear and thyroid antigen in sera from atopic and non-atopic asthmatics compared to healthy controls.
