Long Term Outcomes of Pediatric Liver Transplantation According to Age.
10.3346/jkms.2014.29.3.320
- Author:
Jeik BYUN
1
;
Nam Joon YI
;
Jeong Moo LEE
;
Suk Won SUH
;
Tae YOO
;
Youngrok CHOI
;
Jae Sung KO
;
Jeong Kee SEO
;
Hyeyoung KIM
;
Hae Won LEE
;
Hyun Young KIM
;
Kwang Woong LEE
;
Sung Eun JUNG
;
Seong Cheol LEE
;
Kwi Won PARK
;
Kyung Suk SUH
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. gsleenj@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pediatrics;
Liver Transplantation;
Survival Rate;
Fulminant Hepatitis;
Living Donors;
Liver Transplantation
- MeSH:
Adolescent;
Age Factors;
Child;
Child, Preschool;
End Stage Liver Disease/mortality/*surgery;
Female;
Graft Rejection/epidemiology;
Graft Survival;
Herpesviridae Infections/etiology;
Humans;
Infant;
Liver Transplantation/*adverse effects/*statistics & numerical data;
Lymphoproliferative Disorders/*etiology;
Male;
Proportional Hazards Models;
Risk Factors;
Severity of Illness Index;
Survival Rate;
Treatment Outcome;
Vascular Diseases/etiology
- From:Journal of Korean Medical Science
2014;29(3):320-327
- CountryRepublic of Korea
- Language:English
-
Abstract:
Liver transplantation (LT) has been the key therapy for end stage liver diseases. However, LT in infancy is still understudied. From 1992 to 2010, 152 children had undergone LT in Seoul National University Hospital. Operations were performed on 43 patients aged less than 12 months (Group A) and 109 patients aged over 12 months (Group B). The mean age of the recipients was 7 months in Group A and 74 months in Group B. The patients' survival rates and post-LT complications were analyzed. The mean Pediatric End-stage Liver Disease score was higher in Group A (21.8) than in Group B (13.4) (P = 0.049). Fulminant hepatitis was less common in Group A (4.8%) than in Group B (13.8%) (P = 0.021). The post-transplant lymphoproliferative disorder and portal vein complication were more common in Group A (14.0%, 18.6%) than in Group B (1.8%, 3.7%) (P = 0.005). However, the 1, 5, and 10 yr patient survival rates were 93%, 93%, and 93%, in Group A and 92%, 90%, and 88% in Group B (P = 0.212). The survival outcome of pediatric LT is excellent and similar regardless of age. LTs in infancy are not riskier than those of children.
