The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study.
10.3346/jkms.2014.29.3.370
- Author:
Yonghyeon YUN
1
;
Minki HWANG
;
Jae Hyung PARK
;
Hangsik SHIN
;
Eun Bo SHIM
;
Hui Nam PAK
Author Information
1. Department of Convergence Biomedical Engineering, Daelim University College, Anyang, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Fibrillation;
Complex Fractionated Electrogram;
Simulation Modeling
- MeSH:
Algorithms;
Atrial Fibrillation/*physiopathology;
Body Surface Potential Mapping;
Catheter Ablation;
*Electrocardiography;
Electrodes;
Heart Atria/physiopathology;
Humans;
*Models, Biological
- From:Journal of Korean Medical Science
2014;29(3):370-377
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although complex fractionated electrogram (CFE) is known to be a target for catheter ablation of fibrillation, its physiological meaning in fibrillation wave-dynamics remains to be clarified. We evaluated the spatiotemporal relationships among the parameters of fibrillation wave-dynamics by simulation modeling. We generated maps of CFE-cycle length (CFE-CL), local dominant frequency (LDF), wave break (WB), and phase singularity (PS) of fibrillation in 2-dimensional homogeneous bidomain cardiac modeling (1,000 x 1,000 cells ten Tusscher model). We compared spatiotemporal correlations by dichotomizing each maps into 10 x 10 lattice zones. In spatial distribution, WB and PS showed excellent correlation (R = 0.963, P < 0.001). CFE-CL had weak correlations with WB (R = 0.288, P < 0.001), PS (R = 0.313, P < 0.001), and LDF (R = -0.411, P < 0.001). However, LDF did not show correlation with PS or WB. PSs were mostly distributed at the periphery of low CFE-CL area. Virtual ablation (5% of critical mass) of CFE-CL < 100 ms terminated fibrillation at 14.3 sec, and high LDF ablation (5% of critical mass) changed fibrillation to organized tachycardia, respectively. In homogeneous 2D fibrillation modeling, CFE-CL was weakly correlated with WB, PS, and LDF, spatiotemporally. PSs are mostly positioned at the periphery of low CFE-CL areas, and virtual ablation targeting low CFE-CL regions terminated fibrillation successfully.
