Assessment of the relationship between serum soluble Klotho and carotid intima-media thickness and left ventricular dysfunction in hemodialysis patients.
10.1016/j.krcp.2015.12.006
- Author:
Emad ABDALLAH
1
;
Osama MOSBAH
;
Ghada KHALIFA
;
Amna METWALY
;
Omnia EL-BENDARY
Author Information
1. Department of Nephrology, Theodor Bilharz Research Institute, Giza, Egypt. drabdallah96@gmail.com
- Publication Type:Original Article
- Keywords:
Cardiovascular diseases;
End-stage renal disease;
Fibroblast growth factor-23;
Soluble Klotho
- MeSH:
C-Reactive Protein;
Calcium;
Cardiovascular Diseases;
Carotid Intima-Media Thickness*;
Coronary Artery Disease;
Cross-Sectional Studies;
Echocardiography;
Enzyme-Linked Immunosorbent Assay;
Fibroblasts;
Humans;
Kidney Failure, Chronic;
Parathyroid Hormone;
Phosphorus;
Renal Dialysis*;
Ventricular Dysfunction, Left*
- From:Kidney Research and Clinical Practice
2016;35(1):42-49
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of our study was to assess the relationship between soluble Klotho (s-Klotho) and carotid intima-media thickness (CIMT) and left ventricular (LV) dysfunction in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 88 patients with end-stage renal disease on regular HD. Serum levels of calcium, phosphorus, parathyroid hormone, and C-reactive protein were measured. The serum levels of s-Klotho and fibroblast growth factor-23 (FGF-23) were measured using an Enzyme linked immunosorbent assay (ELISA) kit. Echocardiography and measurement of CIMT were also conducted. The studied patients were divided according to the median s-Klotho level into 2 groups: patients with low s-Klotho (Group I) and patients with high s-Klotho (Group II). RESULTS: Mean value of s-Klotho was significantly low in HD patients compared to controls (P = 0.001), and mean value of FGF-23 was significantly high in HD patients compared to controls (P = 0.001). The mean values of parathyroid hormone, FGF-23, and phosphorus were significantly high in Group I compared to Group II, whereas the mean value of serum calcium was significantly low in Group I compared to Group II. The mean values of CIMT, LV mass (LVM), LVM index, and LV ejection fraction (LVEF) were high in Group I compared to Group II. Patients with low s-Klotho had significantly more coronary artery disease (CAD). In a regression analysis of s-Klotho with different markers of cardiovascular diseases, s-Klotho showed significant association with CIMT, LVEF, and CAD, but not with LVM and LVM index. CONCLUSION: The present study showed that patients with a low s-Klotho were more often associated with increased CIMT, LV dysfunction, and CAD, and it seems that there was independent association between s-Klotho and CIMT, LVEF, and CAD.
