Effects of Isosorbide Dinitrate(Isoket(R)) on Coronary Perfusion Pressure during the Cardiopulmonary Resuscitation.
10.4097/kjae.1998.35.2.252
- Author:
Jae Kyu CHEUN
1
;
Young Ho JANG
;
Jin Mo KIM
;
Bum Soo CHEUN
Author Information
1. Department of Anesthesiology, School Medicine, Keimyung University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Heart: cardiopulmonary resuscitation;
coronary perfusion
- MeSH:
Animals;
Cardiopulmonary Resuscitation*;
Dogs;
Heart;
Heart Arrest;
Isosorbide Dinitrate;
Isosorbide*;
Perfusion*;
Pulmonary Wedge Pressure;
Resuscitation
- From:Korean Journal of Anesthesiology
1998;35(2):252-258
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Coronary perfusion pressure(CPP) is the most important factor for the success of cardiopulmonary resuscitation(CPR). Therefore, CPP must be optimized during the resuscitation. The purpose of this study is to investigate the effects of isosorbide dinitrate(Isoket(R)) on CPP during CPR. METHODS: 10 Korean dogs were divided into two groups: Group I(N=5) was resuscitated with infusion of isosorbide dinitrate(1 microgram /kg/min) and Group II(N=5) was resuscitated without using isosorbide dinitrate. Following CPR, the heart rate(HR), blood pressure(BP), pulmonary capillary wedge pressure, cardiac output(CO), CPP and endocardial viability ratio(EVR) were measured repeatedly. RESULTS: The changes in HR were not significantly different between the two groups but systolic and diastolic BP, CO, CPP and EVR were well maintained in group 1. CONCLUSIONS: These results suggest that the usual dosage of isosorbide dinitrate is effective in improving CPP and EVR on CPR after impending cardiac arrest.
