Everolimus-Induced Interstitial Pneumonitis in a Patient with Metastatic Renal Cell Carcinoma: a Case Report.
- Author:
So Ra LEE
1
;
Young Min KIM
;
Ji Yun JUNG
;
Hyung Joon KIM
;
Doh Hyung KIM
;
Keon Woo PARK
;
Soon Il LEE
Author Information
1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. avnrt@hanmail.net
- Publication Type:Case Report
- Keywords:
Clear cell metastatic renal cell carcinoma;
Everolimus;
Interstitial pneumonitis
- MeSH:
Carcinoma, Renal Cell;
Disease-Free Survival;
Humans;
Indoles;
Lung Diseases, Interstitial;
Niacinamide;
Phenylurea Compounds;
Protein-Tyrosine Kinases;
Pyrroles;
Receptors, Vascular Endothelial Growth Factor;
Sirolimus;
Everolimus
- From:Korean Journal of Medicine
2012;83(4):520-524
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Everolimus, an inhibitor of the mammalian target of rapamycin, is an active agent against metastatic renal cell carcinoma. Treatment with everolimus prolongs progression-free survival in patients with clear cell-type renal cell carcinoma that has progressed on vascular endothelial growth factor receptor tyrosine kinase inhibitors, such as sunitinib and/or sorafenib. Everolimus-induced interstitial pneumonitis is not rare and is sometimes fatal. Due to the potential for pulmonary toxicity due to everolimus, it is recommended that pulmonary complications be periodically evaluated. We report a case of everolimus-associated interstitial pneumonitis in a patient with metastatic renal cell carcinoma.
