Intercellular Adhesion Molecule-1 Gene Polymorphism (K469E) in Korean Preeclamptic Women.
- Author:
Ji Hyae LIM
1
;
So Yeon PARK
;
Shin Young KIM
;
Moon Hee LEE
;
Jae Hyug YANG
;
Moon Young KIM
;
Hyun Young PARK
;
Kwang Soo LEE
;
Young Ju KIM
;
Hyun Mee RYU
Author Information
1. Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea. hmryu@yahoo.com
- Publication Type:Original Article
- Keywords:
Intercellular adhesion molecule-1;
Single-nucleotide polymorphism;
Preeclampsia
- MeSH:
Alleles;
Female;
Genotype;
Humans;
Intercellular Adhesion Molecule-1;
Logistic Models;
Plasma;
Pre-Eclampsia;
Pregnancy
- From:Journal of Genetic Medicine
2008;5(2):105-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Preecalmpsia is a pregnancy-specific disorder that reflects widespread endothelial dysfunction resulting from increases of adhesion molecule expression. Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenetic mechanisms responsible for preeclampsia, and ICAM-1 plasma levels and/or function is genetically influenced. Therefore, we evaluated the distribution of ICAM-1 gene K469E polymorphism in pregnant Korean women with preeclampsia and evaluated the association between this polymorphism and preeclampsia. METHODS: The K469E polymorphism was analyzed in peripheral blood samples from 197 preeclamptic pregnancies and 193 normotensive pregnancies by a SNapShot kit and an ABI Prism 3100 Genetic analyzer. RESULTS: Genotypic and allelic frequencies of ICAM-1 gene polymorphism (K469E) did not differ between preeclamptic and normotensive pregnancies. The distributions of the KK, KE, and EE genotypes were 40.6%, 43.7%, and 15.7%, respectively, in preeclamptic pregnancies and 38.9%, 45.1%, and 16.1%, respectively, in normotensive pregnancies. The frequencies of K and E alleles were 0.62 and 0.38, respectively, in preeclamptic pregnancies and 0.61 and 0.39, respectively, in normotensive pregnancies. By multiple logistic regression analysis, there was no increased risk of preeclampsia in subjects with ICAM-1 KE (OR, 1.08; P=0.74) or EE (OR, 1.07; P=0.88) genotypes. CONCLUSION: This study suggests that the ICAM-1 gene K469E polymorphism does not associate with an increased risk of preeclampsia in pregnant Korean women.
