Diabetes and Osteoporosis.
10.4093/kdj.2009.33.3.169
- Author:
Ki Won OH
1
Author Information
1. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Adipokines;
Diabetes mellitus;
Insulin;
Insulin-like growth factor-I;
Obesity;
Osteoporosis;
PPAR gamma
- MeSH:
Adipokines;
Anabolic Agents;
Bone Remodeling;
Cohort Studies;
Diabetes Mellitus;
Humans;
Incidence;
Insulin;
Insulin-Like Growth Factor I;
Life Expectancy;
Obesity;
Osteogenesis;
Osteoporosis;
PPAR gamma;
Risk Factors
- From:Korean Diabetes Journal
2009;33(3):169-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of insulin and insulin-like growth factor I (IGF-I) system. Several clinical studies have reported adverse skeletal actions of peroxisome proliferator-activated receptor gamma (PPARgamma) agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but also by modulating adipokines that are known to affect bone remodeling.
