No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation.
- Author:
Seongsoo HWANG
1
;
Yi Deun JUNG
;
Kahee CHO
;
Sun A OCK
;
Keon Bong OH
;
Heui Soo KIM
;
Ik Jin YUN
;
Curie AHN
;
Jin Ki PARK
;
Seoki IM
Author Information
- Publication Type:Case Report
- Keywords: PERV transmission; GT-KO pigs; cynomolgus monkey; xenotransplantation; blood cells
- MeSH: Blood Cells; Endogenous Retroviruses*; Haplorhini*; Heart; Heterografts; Macaca fascicularis; Primates; Swine; Transplantation, Heterologous*
- From:Laboratory Animal Research 2014;30(2):90-93
- CountryRepublic of Korea
- Language:English
- Abstract: This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from alpha-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
