Diagnostic Value of Preoperative Serum Thyroglobulin Measurement for the Diagnosis of Malignancy in Follicular or Hurthle Cell Neoplasms of the Thyroid Gland.
- Author:
Nam Kyu KIM
1
;
Seong Joo KANG
;
Weon Hyoung LEE
;
Go Eun YEO
;
You Jin HAN
;
Bu Kyung KIM
;
Su Kyoung KWON
;
Yo Han PARK
;
Young Sik CHOI
Author Information
- Publication Type:Original Article
- Keywords: Follicular neoplasm; Hurthle cell neoplasm; Serum thyroglobulin; Thyroid carcinoma
- MeSH: Biopsy, Fine-Needle; Diagnosis*; Female; Humans; Logistic Models; Male; Retrospective Studies; Thyroglobulin*; Thyroid Gland*; Thyroid Neoplasms
- From:Kosin Medical Journal 2014;29(1):17-22
- CountryRepublic of Korea
- Language:Korean
- Abstract: OBJECTIVES: The aim of this retrospective study was whether serum Tg predicts malignancy in follicular or Hurthle-cell neoplasms on fine needle aspiration. METHODS: A chart review of 111 patients (90 females, 21 males; mean age 46.8 +/- 11.9 years) with follicular or Hurthle-cell neoplasms on fine needle aspiration, who were surgically treated between Sep. 2001 and Sep. 2011, was performed. Predictive factors for malignancy were identified by the chi-squared test and multivariate logistic regression. RESULTS: There were no differences between 41 malignant and 70 benign lesions in serum Tg or any of the normalized indexes. Receiver-operator characteristic analysis revealed no cut-off value. Lesions with serum Tg levels greater than 500 g/L had no significant difference. And also there were no independent predictors of malignancy by multivariate logistic regression. CONCLUSIONS: In this study, the author found that serum Tg has poor accuracy for predicting malignancy in follicular or Hurthle cell neoplasms on fine needle aspiration.
