The Effects of Antidepressant Treatment on Serum Cytokines and Nutritional Status in Hemodialysis Patients.
10.3346/jkms.2004.19.3.384
- Author:
Sang Kyu LEE
1
;
Hong Seock LEE
;
Tae Byeong LEE
;
Do Hoon KIM
;
Ja Ryong KOO
;
Yong Ku KIM
;
Bong Ki SON
Author Information
1. Department of Psychiatry, College of Medicine, Hallym University, Chunchon, Korea. bkson@hallym.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Depression;
Antidepressive Agents;
Cytokines;
Nutritional Status;
Renal Dialysis
- MeSH:
Adult;
Antidepressive Agents, Second-Generation/*pharmacology;
C-Reactive Protein/biosynthesis;
Cytokines/*blood;
Depression/*drug therapy;
Electric Impedance;
Female;
Fluoxetine/*pharmacology;
Human;
Interleukin-1/blood;
Interleukin-2/blood;
Interleukin-6/blood;
Male;
Middle Aged;
Nutrition;
Renal Dialysis/*methods;
Support, Non-U.S. Gov't;
Treatment Outcome;
Tumor Necrosis Factor/biosynthesis
- From:Journal of Korean Medical Science
2004;19(3):384-389
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate the effects of antidepressant treatment on serum cytokines and nutritional status in hemodialysis patients. Twenty-eight hemodialysis patients with a depressed mood were given 20 mg of fluoxetine for 8 weeks. The degree of depressive symptoms, the serum levels of interleukin-1beta, interleukin- 2, interleukin-6, tumor necrosis factor-alpha, c-reactive protein, and markers of nutritional status were assessed at baseline and after treatment. The outcome was assessed in terms of response to treatment (>50% reduction in the score of the Hamilton depression rating scale). Antidepressant treatment decreased the serum level of interleukin- 1 in both response and nonresponse groups, and increased the serum level of interleukin-6 only in the response group. At baseline, the level of interleukin-6 in the response group was lower than in the nonresponse group. Antidepressant treatment also increased fat distribution significantly in the response group which might have slightly improved the nutritional status. This study suggests that antidepressant treatment improve depressive symptoms and may affect immunological functions and nutritional status in chronic hemodialysis patients with depression.
